Dr. Alvaro Becerra Farfán

Dr. Álvaro A. Becerra Farfán
Coordinador académico de Biología Celular, Genética y Morfología

Alvaro Becerra es Licenciado y titulado de Bioquímico por la Universidad Andrés Bello de Chile. Además, cuenta con un Magíster en Bioquímica y un Doctorado en Biociencias Moleculares por la misma casa de estudios. Cuenta con más de 10 años de trabajo enfocado en investigar los mecanismos fisiopatológicos asociados a la disfunción endotelio/vascular y los procesos regenerativos asociados. Con amplia experiencia en docencia universitaria e innovación. Ha publicado más de 10 artículos científicos en destacadas revistas internacionales. Posee una extensa práctica en proyectos de investigación, tanto Básica como Aplicada. Actualmente se desempeña como coordinador académico del Departamento de ciencias Químicas y Biológicas para el área de Biología Celular, Genética y Morfología. [email protected]

Líneas de Investigación.

• Desarrollo de sistemas para sensorizar patrones fisiológicos. Desarrollo de dispositivos basados en IA, que permiten registrar patrones fisiológicos o fisiopatológicos dependiendo del uso y usuario final
• Estudio de mecanismos inflamatorios: Identificación de nuevas moléculas con capacidades antiinflamatorias/antioxidantes /regenerativas.

Publicaciones

• Alvaro Becerra , Felipe Soto , Daniela Millán, Juan José Valenzuela-Fuenzalida, Juan Leon Rojas, Manuel Cortes, 2026, Bioactive Components of Parthenocissus quinquefolia with Antioxidant and Anti-Inflammatory Properties: A Systematic Review, Antioxidants
• Felipe Soto , Juan Valenzuela, Alvaro Gonzalez, Alvaro Becerra , 2026, Síntomas de Encefalomielitis mialgica/síndrome de fatiga crónica en pacientes con COVID prolongado. Una Revisión Sistemática, Revista de la Facultad de Medicina
• Alvaro Becerra Farfan, Nicolás Rebolledo, Felipe Soto , Juan José Valenzuela-Fuenzalida, Jessica Paola Loaiza-Giraldo, Álvaro González a, Alejandro Vallejos b, Juan Sanchis- Gimeno f, José E León- Rojas, 2026, Sepsis-induced neuromuscular dysfunction: A systematic review with meta-analysis, Journal of Infection and Public Health
• Alvaro Becerra Farfan, Felipe Soto , Daniela Millán, Juan José Valenzuela-Fuenzalida, Juan Leon Rojas, Manuel Cortes, 2026, Antioxidant and Anti-Inflammatory Properties of Buddleja globosa Hope (Matico): A Systematic Review of Phytochemical Composition, Molecular Mechanisms, and Translational Evidence, Antioxidants
• Juan José Valenzuela-Fuenzalida, Camila Ignacia Núñez-Castro, Valeria Belén Morán-Durán, Pablo Nova-Baeza, Mathias Orellana-Donoso, Alejandra Suazo-Santibáñez, Alvaro Becerra-Farfan, Gustavo Oyanedel-Amaro, Alejandro Bruna-Mejias, Guinevere Granite, Daniel Casanova-Martinez, Juan Sanchis-Gimeno, 2025, Anatomical Variants in Pancreatic Irrigation and Their Clinical Considerations for the Pancreatic Approach and Surrounding Structures: A Systematic Review with Meta-Analysis, Medicina
• Juan José Valenzuela-Fuenzalida, Antonia Beas-Gambi,, Josefa Matta-Leiva, Daniela Martínez-Hernández, Daniel Milos, Mathias Orellana-Donoso, Alejandra Suazo Santibáñez, Alejandro Bruna-Mejias, Andres Sebastian Riveros, Alvaro Becerra-Farfan, Juan Sanchis-Gimeno, Héctor Gutierrez-Espinoza, Carlos Bastidas-Caldes, 2025, A Systematic Review and Meta-Analysis on the Prevalence of Variants in the Pancreaticobiliary Duct Junction and Its Association with Cancer, Biomedicines.
• Juan José Valenzuela-Fuenzalida, Javiera Cornejo-Peña, Josefina Martinez-Cid, Cristobal Rojas-Acuña, Álvaro Becerra-Farfan, Marko Konchaske, 2025, Arcuate foramen of the atlas vertebra and its correlation with clinical implications in the craniocervical region: A systematic review and meta-analysis, World Neurosurgery
• Juan José Valenzuela-Fuenzalida, Camila Ignacia Núñez-Castro, Valeria Belén Morán-Durán, Pablo Nova-Baeza, Alvaro Becerra-Farfan, Gustavo Oyanedel-Amaro, Alejandro Bruna-Mejias, Guinevere Granite, Daniel Casanova-Martinez, Juan Sanchis-Gimeno, 2025, Anatomical Variants in Pancreatic Irrigation and Their Clinical Considerations for the Pancreatic Approach and Surrounding Structures: A Systematic Review
•  with Meta-Analysis, Medicina»
• Lidija Hofmann, Dalibor Jeremic,  Luis E. León, Alvaro Becerra, ∙ Nuno Sepúlveda, ∙ Francisco Westermeier, 2025, Sex-related cardiometabolic differences in ME/CFS patients, Heliyon
• Juan José Valenzuela-Fuenzalida, Mathias Orellana-Donoso, Daniela Perez-Jiménez, Emilio Farfán-Cabello, Marjorie Gold-Semmler, Alvaro Becerra-Farfan, Camila Román, Pablo Nova-Baeza, 2024, Systematic review and meta-analysis of right subclavian artery variants and their correlation with cervical-thoracic clinical conditions, Medicine.
• Álvaro Alejandro Becerra Farfán,, Manuel Enrique Cortés Cortés, 2024, Desafíos para la enseñanza de la asignatura de Morfología Humana en tiempos de pandemia por COVID-19: Lecciones y oportunidades ante futuras crisis, Revista Cubana de Investigaciones Biomédicas.
• Alejandro Bruna-Mejias, Javiera del Villar-Valdebenito, Camila Roman, Catalina Alcaíno-Adasme, Walter Sepulveda-Loyola,, Alvaro Becerra-Farfan, 2024, Hypoplastic  and Congenital Absence of Coronary Arteries and Its Correlation with Clinical Implications of Cardiac Circulation: A Systematic Review and  Meta-Analysis, Clinical Medicine.
• Juan José Valenzuela-Fuenzalida, Constanza Pamela Rojas-Navia, Amanda Paz Quirós-Clavero, Juan Sanchis-Gimeno, Macarena Rodriguez-Luengo, Pablo Nova-Baeza, Mathias Orellana-Donoso, Álvaro Becerra Farfán, Constanza Pamela Rojas-Navia, Amanda Paz Quirós-Clavero, Juan Sanchis-Gimeno, Pablo Nova-Baeza, Álvaro Becerra Farfán, 2024, Anatomy  of vertebral artery hypoplasia and its relationship with clinical  implications: a systematic review and meta-analysis of prevalence, Surgical and Radiologic Anatomy.
• Alejandro Bruna-Mejias, Vicente Baeza, Javiera Gamboa, Belen Baez Flores, Jessica San Martin, Constanza Astorga, Javiera Leyton, Pablo Nova-Baeza, Mathias Orellana-Donoso, Alejandra Suazo-Santibañez, Alvaro Becerra-Farfán, Vicente Baeza, Javiera Gamboa, Constanza Astorga, Mathias Orellana-Donoso,, Álvaro Becerra Farfán, 2024, Use of Ketamine in Patients with Multifactorial Neuropathic Pain: A Systematic Review and Meta-Analysis, Pharmaceuticals.
• Alvaro Becerra , 2023, Measuring ROS and Oxidative Damage in Human Health: Relevance and Methodological Considerations, Biomedical Journal of Scientific & Technical Research.
• Juan José Valenzuela-Fuenzalida, Daniela Martínez-Hernández,,  Daniela Pérez-Jiménez, , Álvaro Becerra-Farfan, 2023, Prevalence and clinical consideration of anatomical variants of the splenic artery: a systematic review and meta-analysis, Applied Sciences.
• Juan José Valenzuela-Fuenzalida,,  Vicente Baeza-Garrido, , María Fernanda Navia-Ramírez, , Álvaro Becerra-Farfan, 2023, Systematic Review and Meta-Analysis: Recurrent Laryngeal Nerve Variants and Their Implication in Surgery and Neck Pathologies, Using the Anatomical Quality Assurance (AQUA) Checklist, Life.
• Pablo Tapia, Sebastian Gatica, Cristian Cortés-Rivera, Carolina Otero, Alvaro Becerra, Claudia A. Riedel, Claudio Cabello-Verrugio, Alexis M. Kalergis, Felipe Simon, Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction/ Critical care medicine, Critical Care Medicine, (2019), 9.
• Mauricio A. Lillo, Pablo S. Gaete, Mariela Puebla, Nicolas M. Ardiles, Ines Poblete, Alvaro Becerra, Felipe Simon, Xavier F. Figueroa, Critical contribution of Na+-Ca2+ exchanger to the Ca2+-mediated vasodilation activated in endothelial cells of resistance arteries, The FASEB Journal, (2018), 10.
• MA Valdivia-González, WA Díaz-Vásquez, D Ruiz-León, Alvaro Becerra, DR Aguayo, JM Pérez-Donoso, CC Vásquez (2018) A comparative analysis of tellurite detoxification by members of the genus Shewanella/ Microbial Cell Factories. Archives of microbiology 200 (2), 267-273.
• Alvaro Becerra, Macarena Rojas, Alejandro Vallejos, Vicente Villegas, Lorena Pérez, Claudio Cabello-Verrugio, Felipe Simon. (2017) Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-β1/ALK5/Smad pathway. Laboratory Investigation 97 (9), 1033 (filiación UBO)
• Mauricio A Lillo, Pablo S Gaete, Mariela Puebla, Nicolás M Ardiles, Inés Poblete, Alvaro Becerra, Felipe Simon, Xavier F Figueroa (2017) Critical contribution of Na+-Ca2+ exchanger to the Ca2+-mediated vasodilation activated in endothelial cells of resistance arteries. The FASEB Journal, fj. 201700365RR (filiación UBO)
• Alejandro A Arriagada, Eduardo Albornoz, Ma Cecilia Opazo, Alvaro Becerra, Gonzalo Vidal, Carlos Fardella, Luis Michea, Nancy Carrasco, Felipe Simon, Alvaro A Elorza, Susan M Bueno, Alexis M Kalergis, Claudia A Riedel (2015)Excess Iodide Induces an Acute Inhibition of the Sodium/Iodide Symporter in thyroid rat cells by Increasing Reactive Oxygen Species. Endocrinology 156 (4), 1540-1551.
• Daniela Sarmiento, Ignacio Montorfano, Oscar Cerda, Mónica Cáceres, Alvaro Becerra, Claudio Cabello-Verrugio, Alvaro A Elorza, Claudia Riedel, Pablo Tapia, Luis A Velásquez, Diego Varela, Felipe Simon (2015). Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel. Microvascular research 98, 187-196
• Ignacio Montorfano, Alvaro Becerra, Roberto Cerro, César Echeverría, Elizabeth Sáez, María Gabriela Morales, Ricardo Fernández, Claudio Cabello-Verrugio, Felipe Simon (2014) Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-β1 and TGF-β2-dependent pathway. Laboratory investigation 94 (10), 1068
• César Echeverría, Ignacio Montorfano, Daniela Sarmiento, Alvaro Becerra, Felipe Nuñez‐Villena, Xavier F Figueroa, Claudio Cabello‐Verrugio, Alvaro A Elorza, Claudia Riedel, Felipe Simon (2013) Lipopolysaccharide induces a Fibrotic-like phenotype in endothelial cells/Journal of cellular and molecular medicine. Journal of cellular and molecular medicine 17 (6), 800-814
• Cesar Echeverría, Alvaro Becerra, Felipe Nuñez-Villena, Alvaro Muñoz-Castro, Jimmy Stehberg, Zhiping Zheng, Ramiro Arratia-Perez, Felipe Simon, Rodrigo Ramírez-Tagle (2012) The paramagnetic and luminescent [Re6Se8I6]3- cluster. Its potential use as an antitumoral and biomarker agent/New Journal of Chemistry. New journal of chemistry 36 (4), 927-932
• Jimmy Stehberg, Rodrigo Moraga-Amaro, Christian Salazar, Alvaro Becerra, Cesar Echeverría, Juan A Orellana, Geert Bultynck, Raf Ponsaerts, Luc Leybaert, Felipe Simon, Juan C Sáez, Mauricio A Retamal (2012) Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. The FASEB Journal 26 (9), 3649-3657
• Alvaro Becerra, Cesar Echeverría, Diego Varela, Daniela Sarmiento, Ricardo Armisén, Felipe Nuñez-Villena, Mario Montecinos, Felipe Simon (2011) Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death. Cardiovascular research 91 (4), 677-684
• Claudio Cabello-Verrugio, María José Acuña, María Gabriela Morales, Alvaro Becerra, Felipe Simon, Enrique Brandan (2011) Fibrotic response induced by angiotensin-II requires NAD (P) H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells. Biochemical and biophysical research communications 410 (3), 665-670
• Felipe Nunez-Villena, Alvaro Becerra, Cesar Echeverría, Nicolás Briceno, Omar Porras, Ricardo Armisén, Diego Varela, Ignacio Montorfano, Daniela Sarmiento, Felipe Simon (2011) Increased expression of the Transient Receptor Potential Melastatin 7 channel is critically involved in lipopolysaccharide-induced ROS-mediated neuronal death. Antioxidants & redox signaling 15 (9), 2425-2438
• Ricardo Fernández, Gino Nardocci, Felipe Simon, Aldo Martin, Alvaro Becerra, Carolina Rodríguez-Tirado, Kevin R Maisey, Claudio Acuña-Castillo, Paula P Cortes (2011) Lipopolysaccharide signaling in the carotid chemoreceptor pathway of rats with sepsis syndrome. Respiratory physiology & neurobiology 175 (3), 336-348