Daniel Cabrera García

2Bioquímico, Magíster en Ciencias Biológicas y Doctor en Biología Celular y Molecular de la Pontificia Universidad Católica de Chile. Coordinador del área de Bioquímica y Farmacología. Su investigación se basa en comprender los mecanismos celulares y moleculares involucrados en la pérdida de fuerza y masa muscular como consecuencia del envejecimiento y de patologías crónicas como la cirrosis hepática.

Publicaciones

  • Cabrera D, Gutiérrez J, Cabello-Verrugio C, Morales MG, Mezzano S, Fadic R, Casar JC, Hancke JL, Brandan E. Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis. Skelet Muscle. 2014 Mar 21;4(1):6.
  • Gutiérrez J, Cabrera D, Brandan E. Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism: effect on migration of skeletal muscle precursor cells. Skelet Muscle. 2014 Feb 12;4(1):5. doi: 10.1186/2044-5040-4-5.
  • Acuña MJ, Pessina P, Olguin H, Cabrera D, Vio CP, Bader M, Muñoz-Canoves P, Santos RA, Cabello-Verrugio C, Brandan E. Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling. Hum Mol Genet. 2014 Mar 1;23(5):1237-49. doi: 10.1093/hmg/ddt514. Epub 2013 Oct 24.
  • Morales MG, Gutierrez J, Cabello-Verrugio C, Cabrera D, Lipson KE, Goldschmeding R, Brandan E. Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy. Hum Mol Genet. 2013 Dec 15;22(24):4938-51. doi: 10.1093/hmg/ddt352. Epub 2013 Jul 30.
  • Morales MG, Cabrera D, Céspedes C, Vio CP, Vazquez Y, Brandan E, Cabello-Verrugio C. Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2). Cell Tissue Res. 2013 Jul;353(1):173-87. doi: 10.1007/s00441-013-1642-6. Epub 2013 May 15.
  • Morales MG, Cabello-Verrugio C, Santander C, Cabrera D, Goldschmeding R, Brandan E. CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy. J Pathol. 2011 Dec;225(4):490-501. doi: 10.1002/path.2952. Epub 2011 Aug 8.
  • Cabello-Verrugio C, Morales MG, Cabrera D, Vio CP, Brandan E. Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles. J Cell Mol Med. 2012 Apr;16(4):752-64.
  • Vial C, Gutiérrez J, Santander C, Cabrera D, Brandan E. Decorin interacts with connective tissue growth factor (CTGF)/CCN2 by LRR12 inhibiting its biological activity. J Biol Chem. 2011 Jul 8;286(27):24242-52. doi: 10.1074/jbc.M110.189365. Epub 2011 Mar 23.
  • Mezzano V, Cabrera D, Vial C, Brandan E. Constitutively activated dystrophic muscle fibroblasts show a paradoxical response to TGF-beta and CTGF/CCN2. J Cell Commun Signal. 2007 Dec;1(3-4):205-17. doi: 10.1007/s12079-008-0018-2. Epub 2008 Apr 15.
  • Fadic R, Mezzano V, Alvarez K, Cabrera D, Holmgren J, Brandan E Increase in decorin and biglycan in Duchenne Muscular Dystrophy: role of fibroblasts as cell source of these proteoglycans in the disease. J Cell Mol Med. 2006 Jul-Sep;10 (3):758-69.